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  • Title: Keratitis caused by Candida glabrata in a patient with chronic granulomatous disease.
    Author: Djalilian AR, Smith JA, Walsh TJ, Malech HL, Robinson MR.
    Journal: Am J Ophthalmol; 2001 Nov; 132(5):782-3. PubMed ID: 11704043.
    Abstract:
    PURPOSE: To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease. METHODS: Interventional case report. A 15-year-old boy with chronic granulomatous disease presented with bilateral limbal infiltrates. He had been receiving broad-spectrum systemic antibiotics for recurrent liver abscesses. The keratitis did not respond to antibiotics and did not resolve after a course of topical steroids. RESULTS: Corneal cultures revealed Candida glabrata. The same species was simultaneously isolated from the surgical drainage of the liver abscesses. The ocular and hepatic findings resolved on intravenous amphotericin B. CONCLUSION: Candida glabrata has recently emerged as an important nosocomial pathogen. It may present as a limbal keratitis in the setting of systemic infection.
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