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  • Title: Paget's disease of bone: a disease of the osteoclast.
    Author: Reddy SV, Kurihara N, Menaa C, Roodman GD.
    Journal: Rev Endocr Metab Disord; 2001 Apr; 2(2):195-201. PubMed ID: 11705325.
    Abstract:
    Paget's disease is a chronic focal disease of the skeleton that affects up to 2-3% of the population over the age of 60 years. There is a genetic predisposition for Paget's disease, with one predisposition locus identified on chromosome 18q-21-22. Osteoclasts and osteoclast precursors from Paget's patients are abnormal and appear hyperresponsive to 1,25(OH)2D3 and RANK ligand and contain paramyxoviral transcripts (Fig. 1). The basis for the abnormalities detected in Paget's disease and the role that the paramyxoviruses may play in this disease are still unclear.
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