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  • Title: Insulin-unresponsive tissues respond to superactive insulin-like material.
    Author: Oka T, Topper YJ.
    Journal: Science; 1975 Jun 27; 188(4195):1317-9. PubMed ID: 1170638.
    Abstract:
    Insulin-like material prepared from insulin-Sepharose stimulates glucose oxidation by isolated diaphragm of C57Bl/6J ob/ob mice, but insulin does not. This material is much more effective than insulin on epididymal fat tissue from these mice. Insulin-like material and insulin are equipotent on the corresponding tissues from lean littermates.
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