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  • Title: In vitro activities of a new ketolide, ABT-773, against multidrug-resistant gram-positive cocci.
    Author: Singh KV, Malathum K, Murray BE.
    Journal: Antimicrob Agents Chemother; 2001 Dec; 45(12):3640-3. PubMed ID: 11709359.
    Abstract:
    The in vitro activities of ABT-773 were evaluated against 324 strains of gram-positive bacteria, including multidrug-resistant Staphylococcus spp. and Enterococcus spp. ABT-773 had lower MIC ranges, MICs at which 50% of isolates are inhibited (MIC(50)s), and MIC(90)s than erythromycin or clindamycin for almost all isolates tested. The MICs of ABT-773 were also lower than those of quinupristin-dalfopristin (Q-D) for methicillin-susceptible Staphylococcus aureus, Rhodococcus spp., and Streptococcus spp., while the MICs of Q-D were lower than those of ABT-773 for methicillin-resistant S. aureus and Enterococcus faecium, including vancomycin-resistant isolates.
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