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  • Title: Extractive-spectrophotometric determination of some 2- and 10-disubstituted phenothiazines with dipicrylamine.
    Author: Regulska E, Puzanowska-Tarasiewicz H.
    Journal: Acta Pol Pharm; 2001; 58(3):151-5. PubMed ID: 11712730.
    Abstract:
    Dipicrylamine reacts in neutral medium with some 2,10-disubstituted phenothiazines (promazine, chlorpromazine and promethazine hydrochlorides, trifluoperazine dihydrochloride, thioproperazine dimethanosulphonate) forming orange or brown ion-association compounds. The compounds are insoluble in water but quantitatively extracted into chloroform. These properties have been exploited for the determination of phenothiazines in pure solutions and pharmaceuticals.
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