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  • Title: Effect of disturbed plasma oxidant homeostasis on hemopoietic differentiation of polypotent bone marrow stem cells in mice treated with dipyridamole.
    Author: Ivasenko IN, Shlyakhto EV.
    Journal: Bull Exp Biol Med; 2001 Aug; 132(2):766-8. PubMed ID: 11713561.
    Abstract:
    The choice of hemopoietic differentiation by polypotent bone marrow stem cells was studied by morphological and chemiluminescent methods. This choice occurred on day 7 after heterotopic bone marrow transplantation and dipyridamole administration, under the effect of oxidative homeostasis imbalance in the plasma. Dipyridamole increased total antioxidant activity and 10-fold reduced the intensity of free radical oxidation. Disaggregation therapy with dipyridamole reduced platelet count in the peripheral blood and decreased total plasma antioxidant activity.
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