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  • Title: The clinical experience of antisense therapy to ICAM-1 in Crohn's disease.
    Author: Yacyshyn B, Bowen-Yacyshyn MB, Shanahan W.
    Journal: Curr Opin Mol Ther; 1999 Jun; 1(3):332-5. PubMed ID: 11713798.
    Abstract:
    ISIS-2302 is a 6781.24 amu molecular weight antisense molecule. Its sequence is 5'-GCCCAAGCTGGCATCCGTCA-3'. This 20 base phosphorothioate hybridizes to a sequence in the 3' untranslated region of human ICAM-1 mRNA. This substrate is cleaved by RNase H, resulting in specific message and protein reduction 11,21.
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