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  • Title: Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes.
    Author: Lemberg MK, Bland FA, Weihofen A, Braud VM, Martoglio B.
    Journal: J Immunol; 2001 Dec 01; 167(11):6441-6. PubMed ID: 11714810.
    Abstract:
    Signal sequences of human MHC class I molecules are a unique source of epitopes for newly synthesized nonclassical HLA-E molecules. Binding of such conserved peptides to HLA-E induces its cell surface expression and protects cells from NK cell attack. After cleavage from the pre-protein, we show that the liberated MHC class I signal peptide is further processed by signal peptide peptidase in the hydrophobic, membrane-spanning region. This cut is essential for the release of the HLA-E epitope-containing fragment from the lipid bilayer and its subsequent transport into the lumen of the endoplasmic reticulum via the TAP.
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