These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Pressure-induced depolymerization of brain microtubules in vitro.
    Author: Salmon ED.
    Journal: Science; 1975 Sep 12; 189(4206):884-6. PubMed ID: 1171523.
    Abstract:
    Microtubules, assembled in vitro from tubulin extracted from rabbit brain, were subjected to changes in hydrostatic pressure (200 to 10,000 pounds per square inch) and temperature (37 degrees to 0 degrees C). Increased pressure, like cooling, reversibly depolymerizes microtubules, as measured by changes in either turbidity, birefringence, or the number of microtubules seen in electron micrographs. The characteristic response of brain microtubules in vitro to pressure is similar to that of mitotic spindle microtubules in vivo.
    [Abstract] [Full Text] [Related] [New Search]