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  • Title: [Clinical efficacy of double autologous hematopoietic stem cell transplantation in the treatment of adult acute lymphoblastic leukemia].
    Author: Huang W, Zhang B, Yao S.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2001 Aug; 22(8):399-402. PubMed ID: 11718088.
    Abstract:
    OBJECTIVE: To evaluate the clinical efficacy of double autologous hematopoietic stem cell transplantation (DAHSCT) in adult acute lymphoblastic leukemia and analyse the affecting factors. METHODS: Thirteen adult acute lymphoblastic leukemia (ALL) patients received the first AHSCT in 12 months after complete remission (CR). The first conditioning regimen was Vp16,600-1000 mg or Ara-C 2-4 g/m2, CTX 120 mg/kg, total body irradiation(TBI) 7.5-9.0 Gy and in 6 patients BCNU 125 mg was added. All the patients received the second AHSCT in 4 to 10 months after the first AHSCT. The second conditioning regimen was Vp16,600-1000 mg or Ara-C 2-4 g/m2, Mel 140 mg/m2, CTX 120 mg/kg. RESULTS: All engrafted patients had rapid hematopoietic reconstitution. There was no AHSCT related death. The median follow-up duration was 837 days. Seven of the 13 DAHSCT patients were alive. The 3 year disease-free survival (DFS) was (53.8 +/- 7.7)%. Those who had more lymphoblasts in bone marrow at the second AHSCT than that at the first AHSCT had greater probability of relapse. CONCLUSION: It suggested that DAHSCT could be used as an important treatment owing to its low AHSCT related death and relatively long DFS.
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