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  • Title: [Membranous nephropathy after allogeneic peripheral blood hematopoietic stem cell transplantation--clinicopathologic manifestations of a rare chronic GVHD].
    Author: Yu J, Cui R, Tong S.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2001 Aug; 22(8):415-7. PubMed ID: 11718092.
    Abstract:
    OBJECTIVE: To investigate the clinicopathologic characteristics of renal chronic graft versus host disease (GVHD) after allogeneic peripheral blood hematopoietic transplantation(HSCT). METHODS: Clinical and pathological data from a patient with post-BMT GVHD were analysed with a related references review. RESULTS: The patient developed nephrotic syndrome (NS) 8 months after allogeneic HSCT. Renal biopsy revealed irregular thickening of glomerular basement membrane with granular deposits of IgG along it. Electronic microscopy showed electron dense deposits with increased mesangial matrix and cells in subepithelial and mesangial area. CONCLUSION: NS occurred after HSCT might be an autoimmune glomerulonephritis. Immune suppressor could reduce the incidence of NS in the HSCT patients. Cell-cept had a good efficacy in the treatment and renal biopsy played an important role in the diagnosis and prognosis of renal cGVHD.
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