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  • Title: Glycinergic/GABAergic synapses in the lateral superior olive are excitatory in neonatal C57Bl/6J mice.
    Author: Kullmann PH, Kandler K.
    Journal: Brain Res Dev Brain Res; 2001 Nov 26; 131(1-2):143-7. PubMed ID: 11718844.
    Abstract:
    The lateral superior olive (LSO), a nucleus involved in sound localization, receives tonotopically organized, inhibitory input from the medial nucleus of the trapezoid body (MNTB). To better understand the development of this glycinergic/GABAergic pathway, we used Gramicidin-perforated patch clamp recordings to characterize MNTB-evoked postsynaptic potentials in LSO neurons of neonatal C57Bl/6J mice. We found that during the first postnatal week, MNTB-evoked responses change from being depolarizing to being hyperpolarizing. Most interestingly, depolarizing glycinergic/GABAergic synaptic potentials were able to trigger action potentials, demonstrating that the MNTB-LSO pathway can act as a true excitatory pathway. This transient excitatory action of immature MNTB-LSO synapses might play an important role in activity-dependent sharpening of the tonotopic organization of inhibitory connections in the LSO.
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