These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Activity of a tamoxifen-raloxifene hybrid ligand for estrogen receptors at an AP-1 site.
    Author: Weatherman RV, Carroll DC, Scanlan TS.
    Journal: Bioorg Med Chem Lett; 2001 Dec 17; 11(24):3129-31. PubMed ID: 11720858.
    Abstract:
    To test the effect of ligand flexibility on the selective transcriptional activities of ERalpha and ERbeta from an AP-1 site, an analogue of raloxifene was made that removed the ketone functionality and made the ligand more planar and conformationally more similar to 4-hydroxytamoxifen. Desketoraloxifene was found to be a much stronger activator at an AP-1 site with ERalpha than with ERbeta, mimicking 4-hydroxytamoxifen more than raloxifene.
    [Abstract] [Full Text] [Related] [New Search]