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  • Title: [Deletions and aberrant transcription of p16 and p15 genes in childhood acute lymphoblastic leukemia].
    Author: Fu G, Lu C, Zhang R.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 1999 Jul; 20(7):366-8. PubMed ID: 11721435.
    Abstract:
    OBJECTIVE: To explore the role of p16(MTS1) and p15(MTS2) genes in the pathogenesis of childhood acute lymphoblastic leukemia(ALL). METHODS: PCR and Southern blot were used to analyse p16 and p15 gene deletions, RT-PCR was used to analyse p15 gene transcription. RESULTS: Exon 1 and 2 of p16 gene deletion was detected in 8 of 21 patients(38.1%), and exon 1 and 2 of p15 gene deletion in 11 of 21 patients(52.3%). Aberrant p15 gene transcription was observed in two cases. CONCLUSION: High frequency of p16 and p15 gene deletions and aberrant transcription may be involved in the pathogenesis of childhood ALL.
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