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  • Title: PrP genotype in Sarda breed sheep and its relevance to scrapie. Brief report.
    Author: Vaccari G, Petraroli R, Agrimi U, Eleni C, Perfetti MG, Di Bari MA, Morelli L, Ligios C, Busani L, Nonno R, Di Guardo G.
    Journal: Arch Virol; 2001 Oct; 146(10):2029-37. PubMed ID: 11722022.
    Abstract:
    Several PrP gene polymorphisms modulate sheep scrapie susceptibility. Recently, an increase of scrapie outbreaks has been reported in Italy. A vaccine containing sheep brain homogenate was used in most of the outbreaks. We investigated PrP gene polymorphisms in scrapie-affected and clinically healthy Sarda breed sheep from a flock exposed to the aforementioned vaccine, and in affected Sarda sheep from unexposed flocks. All affected animals were (Gln/Gln)171 homozygous. Moreover, we observed no variation for Ala136 and a new polymorphism (Lys to Asn) at codon 176. Our findings confirm the correlation between scrapie and (Gln/Gln)171 in breeds with no variation for Ala136.
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