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  • Title: Induced synthesis of albumin-like protein in damaged rat reticulocytes.
    Author: Trifunović A, Zarić J, Lusić M, Mijatović M, Glisin V, Popović Z.
    Journal: Br J Haematol; 2001 Oct; 115(1):205-12. PubMed ID: 11722434.
    Abstract:
    In this study, we present evidence that red blood cell (RBC) membrane p68 in the Belgrade (b/b) rat is similar if not identical to rat serum albumin (RSA). Structural homology between RSA and the RBC p68 has been determined by a variety of biochemical and immunological criteria. This albumin-like protein is a normal constituent of rat RBC and it is partially exported by exosomes during erythroid differentiation. The endogenous origin of rat RBC albumin-like protein was demonstrated by monitoring protein synthesis in reticulocytes and by identification of reticulocyte mRNA for albumin. Haemolytic anaemia, either hereditary (b/b rat) or drug-induced (phenylhydrazine-treated normal rat), results in increased accumulation of the albumin-like protein in rat RBCs as a result of its induced synthesis.
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