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  • Title: Paradoxical absence of aggression during naloxone-precipitated morphine withdrawal.
    Author: Gianutsos G, Hynes MD, Drawbaugh RB, Lal H.
    Journal: Psychopharmacologia; 1975 Jul 23; 43(1):43-6. PubMed ID: 1172256.
    Abstract:
    Aggression, which is normally seen during withdrawal from narcotics, could not be produced in morphine-dependent rats by the administration of naloxone at doses which causes other signs of withdrawal. Apomorphine injected instead of naloxone was capable of producing aggression, without other withdrawal signs. Naturally occurring aggression (72-hr withdrawal) was enhanced by apomorphine and unaffected by naloxone.
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