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  • Title: Reduced basal levels and enhanced LPS response of IL-6 mRNA in aged mice.
    Author: Sharman K, Sharman E, Campbell A, Bondy SC.
    Journal: J Gerontol A Biol Sci Med Sci; 2001 Dec; 56(12):B520-3. PubMed ID: 11723144.
    Abstract:
    Senescence is a complex and multifactorial process that may predispose organisms to altered responses to environmental stressors. The cytokine interleukin-6 (IL-6) is expressed by a variety of cells and is one of the earliest mediators of the acute inflammatory response. In this study, the level of IL-6 mRNA in younger (7 months) and old (23 months) mice was determined in the tissue of several organs with or without stimulation with lipopolysaccharide (LPS). Whereas younger animals had a basal expression of IL-6 mRNA in all organs, this was undetectable in the old animals. In contrast, when the mice were injected with LPS, in a majority of the organ tissues there was a robust stimulation of IL-6 mRNA in the old mice whereas the younger animals had a more variable response. These data indicate that the aging process may predispose animals to an exaggerated and potentially harmful inflammatory response.
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