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  • Title: The channel of death.
    Author: Degterev A, Boyce M, Yuan J.
    Journal: J Cell Biol; 2001 Nov 26; 155(5):695-8. PubMed ID: 11724809.
    Abstract:
    The proapoptotic members of the Bcl-2 family have been proposed to participate in the formation of a channel that releases these apoptogenic factors when mitochondria receive apoptotic signals. A recent study provides the first direct, biophysical measurement of a potentially apoptosis-specific mitochondrial channel, which is regulated by Bcl-2 family members and may play a primary role in the release of the proapoptotic factors.
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