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  • Title: Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung.
    Author: Thambisetty MR, Scherzer CR, Yu Z, Lennon VA, Newman NJ.
    Journal: J Neuroophthalmol; 2001 Sep; 21(3):164-7. PubMed ID: 11725180.
    Abstract:
    Bilateral optic neuropathy and subacute cerebellar ataxia were manifestations of a paraneoplastic neurologic disorder in a woman found to have small cell carcinoma of the lung. Serologic tests revealed a neuronal autoantibody specific for CRMP-5, a 62-kd member of the collapsin response-mediating protein family. Unexplained optic neuropathy in the setting of subacute cerebellar ataxia should cause suspicion of a paraneoplastic disorder and prompt testing for this autoantibody, especially in patients at risk for lung carcinoma.
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