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  • Title: Sesquiterpene lactones. Part XIII. Cytotoxic activity of eupatolide and eupatoriopicrin on human and animal malignant cells in tissue culture in vitro.
    Author: Hladoń B, Drozdz B, Grabarczyk H, Bobkiewicz T, Olszewski J.
    Journal: Pol J Pharmacol Pharm; 1975; 27(4):429-38. PubMed ID: 1172616.
    Abstract:
    The activity was determined in tissue culture of KB, HeLa human tumor cells. RK normal animal and EAC-E4 Ehrlich ascites carcinoma cells. Eupatolide (EUP) and eupatoriopicrin (EUPP) show similar cytotoxic activity (ED50 from 0-5 to 1-3 mug/ml), dependent on the cell strain used. In plate test EUP and EUPP give inhibition zones of 18--19 mm. EUPP exerts progressively destructive influence on EAC-E4 cells in the conditions of Miyamura test. The decrease in EUPP activity was noted in aqueous (pH = 9) and acetone solutions.
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