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  • Title: Bilateral trephine bone marrow biopsies in lymphoma and other neoplastic diseases.
    Author: Brunning RD, Bloomfield CD, McKenna RW, Peterson LA.
    Journal: Ann Intern Med; 1975 Mar; 82(3):365-6. PubMed ID: 1172924.
    Abstract:
    We have evaluated the usefulness of bilateral rather than unilateral posterior iliac spine trephine biopsies in searching for lymphoma and other neoplastic diseases in the bone marrow. Two hundred and eighty-two patients with these diseases were studied. Tumor was found on only one side in 22% of patients with non-Hodgkin's malignant lymphoma, in 43% of patients with Hodgkin's disease, and in 36% of patients with other neoplastic processes. Thus, the second biopsy yields an additional 11% to 22% of positive biopsies. We conclude that bilateral trephine bone marrow biopsies should be routinely performed when searching for tumor in the bone marrow.
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