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  • Title: Single-cell analysis of cytokine production shows different immune profiles in multiple sclerosis patients with active or quiescent disease.
    Author: Clerici M, Saresella M, Trabattoni D, Speciale L, Fossati S, Ruzzante S, Cavaretta R, Filippi M, Caputo D, Ferrante P.
    Journal: J Neuroimmunol; 2001 Dec 03; 121(1-2):88-101. PubMed ID: 11730945.
    Abstract:
    Peripheral blood mononuclear cells of multiple sclerosis (MS) patients were stimulated with myelin basic protein (MBP) together with anti-CD28 monoclonal antibody and staphylococcal enterotoxin B to optimize cytokine production by antigen-specific cells. Type 1 (IL-2, IL-12, IFNgamma) and pro-inflammatory (TNFalpha, IL-1beta, IL-6) cytokines were augmented in CD4+, CD8+, and CD14+ cells of acute MS patients and of patients undergoing disease reactivation. These cytokines were reduced in IFNbeta-treated and in stable MS patients; type 2 cytokines (IL-4, IL-10) were increased in these patients. Similar immune profiles are seen in MS patients in whom remission is naturally or pharmacologically (IFNbeta) achieved. Cytokine alterations are particularly evident in CD14+ cells, underlying their critical role in the modulation of the immune response.
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