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  • Title: Childhood idiopathic thrombocytopenic purpura. Aggressive management of life-threatening complications.
    Author: Lightsey AL, McMillan R, Koenig HM.
    Journal: JAMA; 1975 May 19; 232(7):734-6. PubMed ID: 1173173.
    Abstract:
    Idiopathic thrombocytopenic purpura (ITP) in childhood is usually a benign, self-limited illness. Life-threatening complications, such as central nervous system (CNS) hemorrhage, occur in less than 1% of cases. We report a case in which the patient failed to respond to splenectomy and high-dose corticosteroid therapy. Immunosuppressive therapy with cyclophosphamide, vincristine sulfate, and corticosteroids in conjunction with frequent transfusions of platelets was associated with a complete remission that persisted after therapy was discontinued.
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