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  • Title: Effects of apomorphine, ergocornine and piribedil on audiogenic seizures in DBA/2 mice.
    Author: Anlezark GM, Meldrum BS.
    Journal: Br J Pharmacol; 1975 Mar; 53(3):419-21. PubMed ID: 1173346.
    Abstract:
    Audiogenic seizures in DBA/2 mice have been studied after administration of drugs believed to act as dopamine agonists. Apomorphine at 0.4 mg/kg delays all phases of the response, the tonic phase is absent after 2.0 mg/kg; the clonic phase is abolished by 10 mg/kg. Ergocornine (0.5-8.0 mg/kg) produces effects on the latency and occurrence of seizure stages similar to those of apomorphine. Piribedil, ET 495 (4-100 mg/kg) is less potent; even after 100 mg/kg clonic and tonic phases occurred in 50% of the mice.
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