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  • Title: Evaluation of clonidine hydrochloride (Catapres). A new antihypertensive agent.
    Author: Kosman ME.
    Journal: JAMA; 1975 Jul 14; 233(2):174-6. PubMed ID: 1173448.
    Abstract:
    Clonidine hydrochloride is a new antihypertensive agent with a primary site of action in the central nervous system. When administered with a diuretic, it is effective for long-term therapy and may be particularly useful in patients with moderately severe hypertension. Clonidine is comparable to methyldopa in efficacy but may cause side-effects more frequently. The only potentially serious adverse reaction that has been reported is a rebound increase in blood pressure that may occur following rapid withdrawal.
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