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  • Title: The effect of glycerol on the lacrate metabolism in the perfused tat liver.
    Author: Olsen C.
    Journal: Acta Pharmacol Toxicol (Copenh); 1975; 36(Suppl 5):441-7. PubMed ID: 1173533.
    Abstract:
    The effect of glycerol on the lactate metabolism was studied on the perfused rat liver. Addition of glycerol to the perfusion medium caused a significant output of lactate and uptake of pyruvate. The lactate/pyruvate- and beta-hydroxybutyrate/acetoacetate ratios rose indicating an effect of glycerol on the cytoplasmic and mitochondrial redox potentials which became more reduced. The output of lactate by the liver may be a result of the reduction in the redox level induced by the oxidation of glycerol.
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