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  • Title: [Pharmacologic effects in combined use of oxyfedrine and beta-acetyldiogoxin].
    Author: Stroman VF, Hempel R.
    Journal: Arzneimittelforschung; 1975 Mar; 25(3):386-8. PubMed ID: 1174037.
    Abstract:
    In guinea pigs the toxic effect of beta-acetyldigoxin was not increased by simultaneously administered 3-(beta-hydroxy-alpha-methyl-phenethyl-amino)-3'-methoxy-propiophenone (oxy-fedrine). There was no evidence of a potentiation of the glycoside effect by the combination with oxyfedrine (ildamen-Novodigal). The threshold dose for arrhythmia was increased: typical glycoside tachyarrhythmias only occurred after higher infused doses. In anesthetized dogs with heart failure by overdosed pentobarbital, the therapeutic effects of beta-acetyldigoxin were sustained and enhanced by oxyfedrine.
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