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  • Title: [Dose-response relationship of bumetanide in healthy subjects].
    Author: Baethke VR, Kampf D.
    Journal: Arzneimittelforschung; 1975 Apr; 25(4):666-8. PubMed ID: 1174085.
    Abstract:
    A diuretic effect is demonstrated following oral administration of 0.25 mg 3-n-butylamino-4-phenoxy-5-sulfamoylbenzoic acid (bumetanide, Burinex-R), the maximum response apparently not being reached by a dose of 0.5 mg. Within this range the dose-response curve is steep and approximately linear. The pattern of urinary volume and electrolyte excretion bears close resemblance to the "high-ceiling" diuretics known so far. Bumetanide differs from them by a markedly increased potency compared on the basis of molar dosage.
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