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  • Title: Prostate-specific antigen induces osteoplastic changes by an autonomous mechanism.
    Author: Yonou H, Aoyagi Y, Kanomata N, Kamijo T, Oda T, Yokose T, Hasebe T, Nagai K, Hatano T, Ogawa Y, Ochiai A.
    Journal: Biochem Biophys Res Commun; 2001 Dec 21; 289(5):1082-7. PubMed ID: 11741302.
    Abstract:
    The high prevalence of osteoplastic bone metastasis in prostate cancer (PC) is believed to be attributable to the production of osteoblast-stimulating factors by PC cells. Prostate-specific antigen (PSA) is a serine protease and an important serological marker for PC. Exposure of osteoblasts to PSA in vitro was found to result in cell proliferation and marked upregulation of transforming growth factor-beta (TGF-beta) mRNA expression. This PSA-induced increase in osteoblast proliferation was inhibited by anti-TGF-beta antibodies and serine protease inhibitors. In vivo, PSA markedly enhanced osteoplastic changes in human adult bone implanted into NOD/SCID mice without PC cells, and alpha(1)-antichymotrypsin prevented the PSA-induced increase in bone volume. PSA promotes osteoplastic change by activating an osteoblast autonomous mechanism that is independent of the production of bone growth factors by PC cells.
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