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  • Title: beta-Cell death during progression to diabetes.
    Author: Mathis D, Vence L, Benoist C.
    Journal: Nature; 2001 Dec 13; 414(6865):792-8. PubMed ID: 11742411.
    Abstract:
    The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta-cells. Apoptosis of beta-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.
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