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  • Title: Inhibition of nicardipine on amygdala kindling in rats.
    Author: Yue W, Wang L, Zhang F, Zhong WZ, Liu ZT.
    Journal: Acta Pharmacol Sin; 2001 Apr; 22(4):365-8. PubMed ID: 11742591.
    Abstract:
    AIM: To investigate the effects and mechanism of nicardipine, a calcium channel blocker, on amygdala kindling in rats. METHODS: Constant current stimulations were delivered to the right amygdala of the rats once a day. The effects of nicardipine on the development and seizure of amygdala kindling were observed and the content of amino acid neurotransmitters in the brain of kindled rats was determined. RESULTS: Nicardipine (2 mg . kg-1, ip) significantly retarded the development of amygdala kindling (P < 0.01); 2 - 20 mg . kg-1 of nicardipine inhibited amygdala kindled seizure dose-dependently, elevated the afterdischarge threshold, and reduced the Racine's stage; 20 mg . kg-1 of nicardipine significantly increased the content of GABA, a kind of inhibitory amino acid neurotransmitter, in the brain of amygdala kindled rats (P < 0.05). CONCLUSION: Nicardipine inhibits amygdala kindling in rats, and the inhibition mechanism may be related to the blockage of the voltage-operated calcium channels and the enhancement of GABAergic system action in the brain.
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