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  • Title: Some pharmacological properties of 2-aryl-1,3-indandione derivatives.
    Author: Fanelli O.
    Journal: Arzneimittelforschung; 1975 Jun; 25(6):873-7. PubMed ID: 1174324.
    Abstract:
    Some pharmacological properties of indandione derivatives have been studied in laboratory animals. These substances possess anti-inflammatory, analgesic and anti-coagulent effects, as already known for other indandione derivatives. In addition they possess anti-tussive effects in mice. Unfortunately many of these molecules have also ulcerogenic effects. This fact is disappointing for those indandione derivatives which already are in therapeutic use, as G/18 (Uridion¿) and Emandione¿. It appears that compounds which have two Br in R1 and R4 position possess at the same time low toxicity and no ulcerogenic effects in addition to anti-inflammatory (G/21) and also anti-coagulant (G/22) interesting activity.
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