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  • Title: Effects of abrupt and gradual withdrawal from long-term haloperidol treatment on open field behavior of rats.
    Author: Bernardi MM, Neto JP.
    Journal: Psychopharmacology (Berl); 1979 Nov; 65(3):247-50. PubMed ID: 117495.
    Abstract:
    The effects of abrupt and gradual withdrawal from long-term haloperidol treatment on rat open field behavior was studied. Abrupt withdrawal induced a significant increase in all parameters of activity observed except defecation, this increase being higher 72 h after the last haloperidol injection. Results were considered to be a consequence of supersensitivity of central dopaminergic receptors. These differences were almost unobservable in animals gradually withdrawn, thus suggesting that the phenomenon is reversible.
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