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Title: Effects of melittin on isolated papillary muscles of guinea pig. Author: Zhang YL, Yang S, Shi NC, Jiang MH. Journal: Acta Pharmacol Sin; 2001 Aug; 22(8):697-700. PubMed ID: 11749840. Abstract: AIM: To investigate the effect of melittin (Mel) on papillary muscles of guinea pigs. METHODS: Contraction of papillary muscles were examined by conventional method and action potentials (AP) were recorded by standard glass microelectrode technique. RESULTS: Mel (0.5, 3 micromol/L) significantly increased the contractility of guinea pig papillary muscles while 5 micromol/L exerted dual action with a transient decrease followed by an increase of the contractility. Mel shortened the functional refractory period (FRP) at concentrations of 0.5, 3, and 5 micromol/L and increased the automaticity induced by adrenaline (Adr) at 3 and 5 micromol/L. Mel shifted the duration-intensity curve upward at 3 micromol/L. It shortened the action potential duration (APD) of fast action potential (FAP), decreased the action potential amplitude (APA) and resting potential (RP) at 0.5 and 3 micromol/L. As to slow action potential (SAP), Mel 0.8 micromol/L shortened APD20 and APD50, and decreased APA and RP. CONCLUSION: Mel increased the contractility and automaticity of papillary muscles, shortened the FRP, decreased the excitability, shortened the APD, and decreased APA and RP of AP.[Abstract] [Full Text] [Related] [New Search]