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  • Title: Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway.
    Author: Whistler J, Beattie E, von Zastrow M.
    Journal: Sci STKE; 2000 Aug 29; 2000(47):pe1. PubMed ID: 11752604.
    Abstract:
    In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.
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