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  • Title: No significant increase in chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with spiramycin.
    Author: Rencüzoğullari E, Ila HB, Topaktaş M, Kayraldiz A, Budak S, Arslan M.
    Journal: Teratog Carcinog Mutagen; 2002; 22(1):51-8. PubMed ID: 11754387.
    Abstract:
    In this study, the chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) were investigated in human lymphocytes treated with spiramycin antibiotic (trade name, rovamycin). Spiramycin did not induce the CAs and SCEs, and also did not decrease the mitotic index (MI). However, spiramycin decreased the replication index (RI) only at 48 h treatment times.
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