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  • Title: Role of the Nha1 antiporter in regulating K(+) influx in Saccharomyces cerevisiae.
    Author: Bañuelos MA, Ruiz MC, Jiménez A, Souciet JL, Potier S, Ramos J.
    Journal: Yeast; 2002 Jan 15; 19(1):9-15. PubMed ID: 11754478.
    Abstract:
    NHA1 encodes a K(+) (Na(+))/H(+) antiporter in the plasma membrane of Saccharomyces cerevisiae. We report that cells expressing the NHA1 gene contained less K(+) than the mutant lacking the gene when grown without K(+) limitation. They also grew better at low K(+) and showed higher affinity of transport than the nha1 strain. In agreement with the function of an electroneutral cation/H(+) antiporter, the effect was only observed at acidic pH. The improved growth and transport depended on the presence of Trk1p (the main K(+) influx system) and did not require the product of TRK2. We propose that Nha1p regulates the potassium content of the cell and, as a consequence, can affect the activity of the main K(+) influx system (Trk1p).
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