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Title: Synthesis and anti-microbial activities of some pyridinium salts with alkoxymethyl hydrophobic group. Author: Pernak J, Kalewska J, Ksycińska H, Cybulski J. Journal: Eur J Med Chem; 2001; 36(11-12):899-907. PubMed ID: 11755232. Abstract: A novel class of functionalized cationic surfactant has been obtained. The work-up procedure of synthesis is very simple, the yield is high and the pyridinium salts with alkoxymethyl hydrophobic group are easily purified. All the salts examined showed anti-microbial activities. Some of them exhibited strong activity and wide anti-bacterial spectra similar to the activity of benzalkonium chloride. The relationship between chemical structure and anti-microbial activity was analysed by the QSAR method.[Abstract] [Full Text] [Related] [New Search]