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  • Title: Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block.
    Author: Grove SJ, Kaur J, Muir AW, Pow E, Tarver GJ, Zhang MQ.
    Journal: Bioorg Med Chem Lett; 2002 Jan 21; 12(2):193-6. PubMed ID: 11755352.
    Abstract:
    A series of oxyanilinium-based AChE inhibitors have been synthesised and tested for the reversal of vecuronium-induced neuromuscular block. Several compounds, for example 2-hydroxy- and 2-methoxy-N,N-dimethyl-N-allylanilinium bromide (3 and 6) showed comparable reversal potencies to edrophonium and clean in vivo cardiovascular profiles.
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