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  • Title: Prophylactic antipyretic treatment with acetaminophen in acute ischemic stroke: a pilot study.
    Author: Koennecke HC, Leistner S.
    Journal: Neurology; 2001 Dec 26; 57(12):2301-3. PubMed ID: 11756615.
    Abstract:
    Fever is associated with poor outcome in acute stroke. Forty-two consecutive, normothermic patients with acute ischemic stroke were, within 24 hours from symptom onset, randomized to either receive 4 g acetaminophen daily (n = 20) or matched placebo (n = 22). Fever of greater than 37.5 degrees C occurred in 36.4% of patients in the placebo group, compared with 5.0% in the acetaminophen group (Fisher's exact test, p = 0.014). Prophylactic antipyretic treatment with acetaminophen may be effective in the prevention of fever after acute ischemic stroke.
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