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  • Title: [Mechanisms of autoimmunity and therapeutic implications].
    Author: Revillard JP.
    Journal: Rev Prat; 2001 Sep 15; 51(14):1528-33. PubMed ID: 11757267.
    Abstract:
    Autoimmune diseases include systemic or tissue-specific disorders induced by antibodies or CD8+ cytotoxic T lymphocytes and(or) CD4+ T lymphocytes that produce pro-inflammatory type-1 cytokines (gamma interferon and tumour necrosis factor). Some may be triggered by infectious agents. Search for predisposition genes is rapidly progressing. Disease-associated autoantibodies production requires T-B cell co-operation. Current research is focused on the characterisation of peptides processed from autoantigens and that of T lymphocytes involved in the initiation of the process. Those studies might eventually lead to immuno-intervention based on antigen administration aiming at the restoration of natural tolerance.
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