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  • Title: A man with hereditary exostoses and high-grade non-Hodgkin's lymphoma of the bone.
    Author: Neben K, Werner M, Bernd L, Ewerbeck V, Delling G, Ho AD.
    Journal: Ann Hematol; 2001 Nov; 80(11):682-4. PubMed ID: 11757729.
    Abstract:
    Multiple cartilaginous exostoses (MCE) is an autosomal dominant disorder that can lead to malignant transformation from exostoses to a secondary chondrosarcoma. We present a case report of a 52-year-old man with MCE who had a palpable mass at the left shoulder. At the site of the left proximal humerus, a cartilaginous exostosis was localized, suggesting that the tumor developed by a malignant transformation of an exostosis into a secondary chondrosarcoma. Interestingly, a biopsy showed a diffuse large B-cell lymphoma with Burkitt-like features. To our knowledge, the association of high-grade lymphoma and hereditary exostoses has not been described previously. This case demonstrates that a malignant tumor at the location of a cartilaginous exostosis is not necessarily a chondrosarcoma and that a biopsy is an essential part of the diagnostic work-up.
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