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  • Title: [Polyamine content in tissues of 7,12-dimethyl-benz(a)anthracene-induced sarcoma and liver of tumor-carrying rats].
    Author: Berdinskikh NK, Lialiushko NM, Vasnetsova SS, Gutnik HS.
    Journal: Ukr Biokhim Zh (1978); 1979; 51(5):541-3. PubMed ID: 117578.
    Abstract:
    Putrescine in determinable amounts is contained in the tumour tissue, in the liver tissue of normal animals it was not detected by the applied method. The spermidine content in the tumour is also considerably higher, it is 15.-3 times as high as that in the normal liver both per 1 g of fresh tissue and per 1 mg of RNA. The spermine content in the tumours is somewhat lower as compared to its content in the normal liver. The shifts in the contents of polyamines are of the same character both for the liver of rats with carcinogen-induced sarcomas and for tumours. Putrescine is determined in noticeable amounts in the liver of tumour-carrying rats. Thus, the carcinoven-induced sarcoma as well as the liver of rats with sarcomas are characterized by a high content of putrescine and spermidine as well as by a high value of the spermidine/spermine ratio.
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