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  • Title: Chemistry of zerumbone. 2. Regulation of ring bond cleavage and unique antibacterial activities of zerumbone derivatives.
    Author: Kitayama T, Yamamoto K, Utsumi R, Takatani M, Hill RK, Kawai Y, Sawada S, Okamoto T.
    Journal: Biosci Biotechnol Biochem; 2001 Oct; 65(10):2193-9. PubMed ID: 11758909.
    Abstract:
    Further investigation of the chemistry of the eleven-membered cyclic sesquiterpene, zerumbone, the major component of the wild ginger, Zingiber zerumbet Smith, has revealed a new selective epoxidation process, a further example of a novel Favorskii-initiated double ring contraction, and a regiospecific fragmentation of zerumbone dibromide derivatives. Several zerumbone derivatives were found to be selective inhibitors of the growth of gram-positive bacteria.
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