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  • Title: In vivo selection of oxacillinase-mediated ceftazidime resistance in Pseudomonas aeruginosa.
    Author: Leotard S, Poirel L, Leblanc PE, Nordmann P.
    Journal: Microb Drug Resist; 2001; 7(3):273-5. PubMed ID: 11759089.
    Abstract:
    Ceftazidime-susceptible and -resistant Pseudomonas aeruginosa strains were isolated from pulmonary specimens following a treatment with ceftazidime in a patient who developed a nosocomial pneumonia. The ceftazidime-susceptible and -resistant strains were clonally related and harbored a self-transferable approximately 155-kb plasmid. These isolates expressed two OXA-10-like oxacillinases, the narrow-spectrum OXA-35 and the expanded-spectrum OXA-19, respectively, differing by one amino acid substitution. This is the first example of in vivo selection of an extended-spectrum oxacillinase from a restricted-spectrum oxacillinase.
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