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  • Title: Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes.
    Author: Thomas PM, Nasonkin I, Zhang H, Gagel RF, Cote GJ.
    Journal: DNA Seq; 2001; 12(2):131-5. PubMed ID: 11761712.
    Abstract:
    We report the cloning, genomic organization and sequence of the mouse alpha-CALC and beta-CALC genes. The two genes share extensive sequence homology. The transcription units of both genes contain 6 exons. Transcripts of the alpha-CALC gene were found to alternatively include exon 4 or exons 5 and 6. For the beta-CALC gene exon 4 was not detected in transcripts derived from this gene. The predicted mouse alpha-CGRP was found to be identical to rat alpha-CGRP, however, beta-CGRP predicted amino acid sequences revealed three amino acid differences suggesting these residues are not critical to CGRP function.
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