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  • Title: Histiocytic necrotizing lymphadenitis preceding systemic lupus erythematosus.
    Author: Komócsi A, Tóvari E, Pajor L, Czirják L.
    Journal: J Eur Acad Dermatol Venereol; 2001 Sep; 15(5):476-80. PubMed ID: 11763397.
    Abstract:
    Necrotizing histiocytic lymphadenopathy (NHL) is a rarely observed clinical entity that is occasionally associated with systemic lupus erythematosus (SLE). The histological features of the condition have been considered to be indistinguishable from those of lymphadenitis in subjects with SLE, and the clinical symptoms of the two disorders share common features. This report presents the case history of a subject who developed SLE with central nervous system involvement 3 years following onset of Kikuchi's disease (histiocytic necrotizing lymphadenitis). Repeated lymph node biopsies confirmed the diagnosis in relation to the clinical progression. A review of the literature on this topic is also presented.
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