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  • Title: Synthesis and antimicrobial activity of new diazoimidazole derivatives containing an N-acylpyrrolidine ring.
    Author: Varoli L, Burnelli S, Garuti L, Vitali B.
    Journal: Farmaco; 2001 Nov; 56(11):885-90. PubMed ID: 11765041.
    Abstract:
    A series of 4-diazoimidazole-5-carboxamides bearing in position 2 lipophilic substituents was synthesized and their antimicrobial activity was evaluated in vitro against pathogenic Gram-positive, Gram-negative bacteria and fungi. Some compounds presented antifungal activity, particularly two derivatives (1g and 1h) showed good MIC values (10-50 microg/ml) against both moulds and yeasts.
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