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  • Title: [Lipids of the bone tissue in bodies of thoracic vertebrae in scoliosis in rabbits].
    Author: David'ian TG, Gaĭvoronskiĭ GI, Chebotareva MA.
    Journal: Vopr Med Khim; 2001; 47(5):511-6. PubMed ID: 11766262.
    Abstract:
    The content of total lipids, triglycerides, cholesterol and phospholipids in the bone tissue of the bodies of the thoracic vertebrae was investigated in 4.5-, 7- and 12 month old rabbity. The development of scoliosis in two month old animals was induced by the one-sided blockade of the afferent links of the innervation in thoracic region at the extent of four segments (TH6-9). In: experimental scoliosis there were important alternations in the content of the total lipids comparing with the control which are observed only on the level of the primary and of the anterior compensatory curves in 12 months old animals. The content of triglycerides changed even at early stages of the development of scoliosis. A decrease of triglycerides content was observed at the level of the primary curve in rabbits of all ages with experimental scoliosis. Probably it is due to the alteration of neurotrophic processes in the bone tissue. There were similar age-related changes of triglyceride content in both groups of animals. Phospholipids have absolutely another than triglycerides dynamics of the content changes during the scoliosis development. Time-course of phospholipid changes in scoliosis differed from that of triglycerides. In older rabbits with experimental scoliosis the cholesterol content in the bone tissue of vertebral bodies was reduced by 1.5-2 times while in normal animals it remained almost unchanged. The most substantial changes in cholesterol content of the vertebral bone tissue in rabbits with the experimental scoliosis occur in early age (4.5 months) on the level of the primary curve and the posterior compensatory curve. This may be considered as one of the biochemical indicators of the progressing scoliosis.
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